Abstract
THIS report, an extension of one previously made (1), deals with the use of propylthiouracil in 95 patients with toxic goiter during a period of twenty-one months. The group includes 67 patients with toxic nodular goiter (21 males and 46 females), and 28 with toxic diffuse goiter (8 males and 20 females). The average age of the former was 51 years with a duration of the disturbance of 2.7 years; in the latter it was 37 years and the duration 3.7 years. Thirty-four patients, 24 with toxic nodular and 10 with toxic diffuse goiter, had been previously treated with thiouracil, and 9 had had iodine before treatment. The average initial basal metabolic rate of the untreated patients was plus 24 per cent for those with toxic nodular goiter; and plus 30 per cent for those with toxic diffuse goiter. Both types previously treated with thiouracil showed an average initial basal metabolic rate of plus 6 per cent (Table 1).
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