Abstract
Brief Reports1 October 1982Propylhexedrine-Induced Left Ventricular DysfunctionCHARLES H. CROFT, M.D., BRIAN G. FIRTH, M.D.; D. Phil., L. DAVID HILLIS, M.D.CHARLES H. CROFT, M.D.Search for more papers by this author, BRIAN G. FIRTH, M.D.; D. Phil.Search for more papers by this author, L. DAVID HILLIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmphetamine abuse has previously been implicated in the pathogenesis of congenital heart disease (1), necrotizing vasculitis (2), intracranial hemorrhage (3), pulmonary fibrosis, and cor pulmonale (4). Although animal studies have shown a relation between myocardial amphetamine concentrations and toxicity (5), only one patient has been described in whom the chronic use of oral dextroamphetamine was associated with a cardiomyopathy (6). We describe four patients with severe left ventricular dysfunction in association with chronic abuse of the amphetamine analog, propylhexedrine.Between September 1978 and February 1982, four men who were chronic abusers of intravenous propylhexedrine (Benzedrex, Smith Kline & French Laboratories,...
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