Proprietes solubilisantes et structure des solutions aqueuses de sels biliaires dihydroxyles

Abstract

The solubilizing properties of aqueous solutions of isomeric salts, deoxycholate, chenodeoxycholate and ursodeoxycholate for naphthalene and cholesterol have been studied. For both molecules, ursodeoxycholate micelles have the poorest detergent power. Binding of naphthalene to micelles modifies the chemical shifts of the angular methyl groups of the bile salts as determined by 1H NMR. A greater pertubation of the C 19 methyl signal relative to that of the C 18 methyl signal is observed with deoxycholate and chenodeoxycholate but not with ursodeoxycholate. These results suggest a distinct micellar structure for ursodeoxycholate.