Abstract
Infantile hemangioma is one of the most common benign tumors of infancy. The natural evolution includes rapid growth followed by gradual involution. Airway hemangiomas are not that common, but they can lead to dyspnoea, as well as to life-threatening complications.Two children aged 3 months were admitted to the Pediatric Department with difficulties in breathing and with biphasic stridor. They had previously been hospitalized because of the same symptoms and misdiagnosed as having an upper respiratory tract infection. The previous treatment included intravenous or inhaled corticosteroids, without any significant improvement. Laryngoscopy wasperformed for both of the children. There was a mass in the subglottic area with the appearance of a hemangioma causing significant airway stenosis. We started treatment with propranolol at a dose of 1 mg/kg/day twice daily. The dose was gradually increased up to 3 mg/kg/day, under close monitoring. In the first 7 to 10 days after initiation of treatment, we observed a significant improvement of the respiratory distress. The second laryngoscopy showed an almost complete involution of the mass in the subglottis.The focus of this article will be primarily on the clinical presentation and the therapeutic response of subglottic hemangioma, along with a literature review on the subject.
Highlights
Infantile hemangiomas (IH) are the most common benign tumors of infancy
Side effects No No endothelial growth factor A (VEGF-A), glucose transporter (GLUT-1), and IGF-2, which are found in high concentrations during the proliferative phase of IH growth.[4]
Subglottic hemangiomas, rare, can be life threatening with a risk of upper airway obstruction during the first months of a child’s life
Summary
Infantile hemangiomas (IH) are the most common benign tumors of infancy. They appear during the first few days or the first weeks after birth; they grow rapidly followed by gradual involution. Subglottic hemangiomas (SH), commonly located in the subglottis area, are capable of causing airway obstruction. Left without treatment, they can provoke acute respiratory failure with a fatal outcome in. Different therapeutic regimens have been tried in an attempt to resolve quickly the symptoms. This includes intravenous or intralesional corticosteroids, laser surgery, tracheostomy, and surgical resection. The beta-blocker has been the leader in the non-invasive treatment of IH
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