Abstract
There was no significant cocaine-sensitive or reserpine-sensitive accumulation of (—)-propranolol in the isolated rabbit iris. Veratridine did not increase the efflux of (—)-propranolol from the rabbit iris. The experiments are not in favour of a neuronal and/or vesicular accumulation of (—)-propranolol. Hence, our experiments are not in favour of an adrenergic neurone-blocking action of (—)-propranolol in the isolated rabbit iris.Wash-out experiments with the isolated pigmented or non-pigmented (albino) iris, loaded with labelled (—)-propranolol, indicate that there exist binding sites of high affinity in or at pigment cells. These results can explain the long duration of action of beta-adrenoceptor-Mockers in lowering the intraocular pressure in man.KeywordsPigment CellLipophilic SubstanceNeuronal UptakeStorage VesiclePigment IrisThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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