Abstract
Objective: To formulate and evaluate propranolol hydrochloride topical gel for overcoming the limitations and low oral bioavailability associated with conventional therapy.
 Methods: The propranolol hydrochloride topical gels were prepared by the cold mechanical method. The preliminary evaluation and further characterisation studies was conducted to find the optimised formulation. The in vitro release and ex vivo permeation studies were investigated. The histopathological studies and stability studies was also assessed.
 Results: The propranolol hydrochloride topical gel was successfully prepared. The in vitro release of optimized topical propranolol hydrochloride gel formulation (G2) showed the highest cumulative percentage drug release that is, 95.55%±0.15 after 7.5 h. (G2) the formulation showed a higher flux value of 4.61μg/cm2/h. The histopathological study using pig skin revealed that the optimized formulation was found to be safe for topical application.
 Conclusion: The formulated topical gel containing propranolol Hydrochloride seems to be a promising dosage form for enhanced skin delivery of propranolol hydrochloride in treating Infantile Hemangioma.
Highlights
Infantile Hemangioma (IH) is benign vascular tumors or soft tissue tumors of childhood, characterized by endothelial cell proliferation
In addition to the proliferation of endothelial cells, acidosis and perinatal hypoxia increases the secretion of vascular endothelial growth factor (VEGF) by stimulating angiogenesis [6]
Fourier transform infrared (FTIR) spectrum of Hydroxy Propyl Methyl Cellulose (HPMC) showed a characteristic peak in the range of 2889.37 cm-1 represents the presence of C-H stretching of alkane
Summary
Infantile Hemangioma (IH) is benign vascular tumors or soft tissue tumors of childhood, characterized by endothelial cell proliferation. It is usually referred as “Strawberry Hemangiomas” because it appears as a red or blue raised lesion [1]. The orally and intralesionally available therapies are associated with various types of adverse effects, so it is necessary to develop a topical formulation to treat this disease condition. Formulation of topical gels by using the first-line agent like propranolol hydrochloride is considered as efficient for the treatment of Infantile Hemangioma.
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