Abstract
Aim: To develop a propranolol HCL-loaded liposomal nasal formulation for migraine prophylaxis. Materials & methods: Formulated theliposomes through thin layer hydration method andoptimized via design of experiments (DOE). The prepared liposomes werecharacterized forparticle size, zeta potential, PDI, drug entrapmentanddrugloading. Assessed for in vitro release kinetics, ex vivo permeability, histopathologyand stability. Results: Optimized liposomes: 135.52±5.87nm, -19.9±0.075mV, 95.41±0.05% entrapment, 43.37±0.02% loading. Showed immediate (30.07±2.09%) and sustained release (95.69±4.58%) over 10h. Enhanced permeation compared with controls; well-tolerated histopathologically. Conclusion: Liposomal formulation offers promise for intranasal propranolol HCL delivery in migraine prophylaxis, with stability under refrigeration.
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