Abstract
Propranolol lowers serum T3 levels in man by reducing 5′-monodeiodination of T4 to T3. Studies of the effect of propranolol on thyroid function in rats are conflicting and have indicated either no change in serum T3 or T4, a decrease in T4 and/or T3, or a rise in T4. In these earlier studies, propranolol was given orally or ip, and in only one was serum propranolol measured to confirm absorption. In an effort to clarify the effect of propranolol on thyroid hormone metabolism in the rat, and to see if the rat could be used as a model for studying the effect of the drug in man, we infused propranolol in Wistar rats by sc implanted osmotic minipumps for 5 days. T4 to T3 conversion in liver and kidney homogenates, as well as serum total T4, total T3, and per cent dialyzable T4 (%DT4) and T3 (%DT3), were examined in intact an d thyroidectomized, T4-replaced propranolol-treated and control rats. The results showed that, at a mean serum propranolol concentration of 162 ng/ml, serum total T3 fell (P < 0.01) as di...
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