Proposed Two-Steps Procedure of Classification High Dimensional Data with Regularized Logistic Regression

Abstract

The field of Bioinformatics has developed in response to the rapid increase in biological data, particularly high-dimensional gene expression data. Bioinformatics utilizes optimization, computational science, and statistical methods to effectively address challenges in the field of molecular biology. Numerous genes (variables) in gene expression are irrelevant to their study. Gene selection has been demonstrated to be an effective means of enhancing the performance of numerous methods of classification. The job of acquiring significant variables via the use of ranking variable selection (RVS) techniques and then picking the most effective classifier is an enormous challenge in the context of high-dimensional data. in this study, we proposed a new ranking filter method using smooth clipped absolute deviation depending on the resampling technique (RSVS) to obtain a proficient subset of genes with strong classification abilities. This is achieved by merging A screening technique employed as a filtering method in conjunction with Regularized Logistic Regression, such as LASSO,ALASSO,ENET, and MCP. The study involved the utilization of both simulated and real datasets to conduct an empirical evaluation of the proposed approach. The findings indicated that the proposed method outperformed other established methods. it was tested using three publicly data sets about Cancer. The Results demonstrate that the suggested approach is highly effective and viable, thus showing a strong level of performance with regards to accuracy, geometric mean, and the area under the curve. Furthermore, The findings suggest that the genes most often chosen are physiologically associated with the specific form of cancer. Therefore, the method that has been suggested has potential advantages for the classification of cancer via the use of DNA gene expression data within a clinical setting.