Abstract
Assessing tolerance of normal tissues in BNCT is complicated by the mix of high LET and low LET radiations, the constituents of which vary rapidly as a function of depth in tissue. The known dependence of biological effects on the extra-or intracellular distribution of boron further complicates this assessment. First, a method is proposed to estimate the tolerance of normal tissue to low LET radiation for the numbers of fractions anticipated. Then an algorithm is suggested to estimate tolerance to mixed high and low LET radiations. From high LET trials, the CNS tolerance to high LET radiation is known for various beams. In animal tolerance studies, the ratio of observed tolerance to expected tolerance can provide a compound factor to account for the unknowns affecting biological efficacy, e.g., boron localization.
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