Abstract
A model was used for the simulation of the pharmacokinetics of inhaled trichloroethylene (TRI) vapor. Computed data of TRI in alveolar air and of trichloroacetic acid (TCA) and trichloroethanol (TCE) in blood and urine agreed satisfactorily with experimental results obtained by various authors. Biological threshold limit values were calculated for subjects exposed at rest to a steady concentration of 100 ppm of TRI in ambient air, between 0800 and 1200 and between 1300 and 1700, five days week during the whole year. The Monday to Friday range of values for urinary excretion (243--322 mg of TCA/24 h and 288--429 mg of TCE/24 h) roughly corresponded to the findings of several surveys among TRI workers in industry. The hypnotic effect of TCE and/or TRI during steady or fluctuating industrial TRI exposure was discussed with the aid of the model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Scandinavian journal of work, environment & health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
