Abstract
The authors, propose that also a sudden death during pregnancy that remains unexplained after an in-depth autopsy, should be considered as a syndrome and referred with the acronym “SIUDS”, e.g., “Sudden Intrauterine Unexplained Death Syndrome”, like “SIDS” for “Sudden Infant Death Syndrome”. This suggested definition is based on the presence in these pathologies of common developmental abnormalities of both the autonomic nervous system and the cardiac conduction system, associated to the same preventable risk factors.
Highlights
The results obtained on a wide set of sudden unexplained fetal and infant deaths [1] point up common congenital anomalies of the ANS and of the CCS, so indicating that unexplained stillbirth should not be regarded as distinct from Sudden Infant Death Syndrome (SIDS)
Neuropathological investigations performed at the "Lino Rossi" Research Center of the University of Milan have contributed to identify the nature and the localization of these developmental alterations common in unexplained stillbirth and SIDS
The results obtained on a wide set of sudden unexplained fetal and infant deaths [1] point up common congenital anomalies of the ANS and of the CCS, so indicating that unexplained stillbirth should not be regarded as distinct from SIDS
Summary
The results obtained on a wide set of sudden unexplained fetal and infant deaths [1] point up common congenital anomalies of the ANS and of the CCS, so indicating that unexplained stillbirth should not be regarded as distinct from SIDS. Neuropathological investigations performed at the "Lino Rossi" Research Center of the University of Milan (http://users.unimi.it/ centrolinorossi/en/index_en.html) have contributed to identify the nature and the localization of these developmental alterations common in unexplained stillbirth and SIDS.
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