Proportion of Thyroid Malignancy in Simple Multi-nodular Goiter: A Prospective Observational Study in Rajshahi Medical College Hospital

Abstract

Background: Thyroid swelling is a common clinical problem throughout the world. Most of the swellings are benign but someare malignant. Epidemiologically ascertained risk factors for thyroid carcinoma are ionizing radiation, presence of thyroidadenoma and multi-nodular goiter. Objectives: To determine the proportion and type of thyroid carcinoma in simple multi-nodular goiter after surgical resectionon histopathological basis.Materials and methods: This prospective observational study was carried out in the Department of Surgery and Otolaryngology and Head neck surgery of Rajshahi Medical College Hospital from January 2015 to December 2016.The studypopulation consisted of 200 patients who were diagnosed as a simple multi-nodular goiter. Among them 60 samples were fromsurgery and 140 samples from Head neck and otolaryngology wards. All the patients were admitted through OPD with routineplus investigations specific to thyroid including thyroid profile, ultrasonography of neck, FNAC of dominant nodule beforebeing subjected to surgery. Results: Among 200 cases which were included in this study 22 (11%) containing foci of malignancy. Incidence of malignancycommonly occurs in females, papillary carcinoma is being the commonest entity. Conclusion: The incidence of malignancy in simple multi-nodular goiter in this study was 11% that is quite high. So, peopleshould be educated and encouraged to attend the thyroid clinics for proper evaluation and early diagnosis of malignancy.