Abstract
Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.
Highlights
The most commonly prescribed drugs for pain and inflammation treatment are nonsteroidal anti-inflammatory drugs (NSAIDs)
The studies that present these findings suggest the need for research that reveals the true risk of using pump inhibitors (PPIs) with these diseases [11]
Indomethacin is known for its high potential to induce gastric ulcers; this medicine is commonly used in several protocols to evaluate gastroprotective agents in murine models [57,60]
Summary
The most commonly prescribed drugs for pain and inflammation treatment are nonsteroidal anti-inflammatory drugs (NSAIDs). Their beneficial properties have been used in the prevention and treatment of diverse disorders because of the general perception of their safety [1,2,3]. An example of this is the long-term use of aspirin, which decreases the risk of cardiovascular diseases, as well as ischemic stroke, colorectal cancer, and myocardial infarction [3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
