Abstract
Sedation-related colonoscopic perforation (CP) has been under much debate. Our aim was to assess and compare the CP rate during colonoscopy by using sedation with or without propofol adjuvant. All patients who underwent colonoscopic procedure at the WGO Endoscopy Training Center, Siriraj Hospital, Thailand from March 2005 to October 2007 by using the intravenous sedation (IVS) technique were analyzed. The primary outcome was the CP rate; the secondary outcomes were sedation-related complications and death during and immediately after the procedure. There were 6140 colonos-copies and 1532 flexible sigmoidoscopies during the study period, of which 6122 colonoscopic procedures were performed by using IVS. All of these procedures were categorized into two groups: group A, the IVS technique was propofol-based sedation and group B, the IVS technique was non-propofol-based sedation. After matching the indications of procedure, there were 2022 colonoscopies in group A and 512 colonoscopies in group B. Colonoscopic procedures were performed by staff endoscopists (10.8%) or residents and fellows (89.2%). The characteristics of patients and sedative agents used in perforated patients in both groups were not significantly different. In group A, five patients (0.25%) suffered from perforation and two of them died. In group B, one patient (0.20%) had CP; the difference was not significant (P=0.829). Our data showed that colonoscopy under propofol-based sedation did not increase the perforation rate. Serious complications are uncommon.
Highlights
Study designThis is a retrospective descriptive study
A total of 7672 consecutive patients from the WGO Endoscopy Training Center, Siriraj Hospital, Bangkok, Thailand were eligible for the study
Exclusion criteria were patients younger than 18 years of age, procedures performed in the intensive care units, procedures performed without sedation, or procedures performed
Summary
A total of 7672 consecutive patients from the WGO Endoscopy Training Center, Siriraj Hospital, Bangkok, Thailand were eligible for the study. These patients underwent colonosscopies (6140) and flexible sigmoidoscopies (1532) from March 2005 to October 2007. Exclusion criteria were patients younger than 18 years of age, procedures performed in the intensive care units, procedures performed without sedation, or procedures performed. These complications were defined as: hypertension or hypotension (increase or decrease in blood pressure by 20% from baseline and above or below normal for age); tachycardia or bradycardia (increase or decrease in heart rate by 20% from baseline and above or below normal for age); any cardiac arrhythmias; hypoxia (oxygen desaturation, SpO2
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
