Abstract
Anesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery. Beyond being an anesthetic used for general anesthesia and sedation, intravenous hypnotic propofol displays an effect on glucose metabolism. To extend the scope of propofol studies, its effects on glucose metabolism were evaluated in male Sprague-Dawley rats of various ages. Unlike chloral hydrate and isoflurane, propofol had little effect on basal glucose levels in rats at 2 months of age, although it did reduce chloral hydrate- and isoflurane-induced hyperglycemia. Propofol reduced postload glucose levels after either intraperitoneal or oral administration of glucose in both 7- and 12-month-old rats, but not those at 2 months of age. These improved effects regarding propofol on glucose metabolism were accompanied by an increase in insulin, fibroblast growth factor-21 (FGF-21), and glucagon-like peptide-1 (GLP-1) secretion. Additionally, an increase in hepatic FGF-21 expression, GLP-1 signaling, and FGF-21 signaling, along with a decrease in endoplasmic reticulum (ER) stress, were noted in propofol-treated rats at 7 months of age. Current findings imply that propofol may turn into insulin-sensitizing molecules during situations of existing insulin resistance, which involve FGF-21, GLP-1, and ER stress.
Highlights
Anesthetics administered to patients undergoing surgery and to and critically ill patientsAnestheticsare areroutinely routinely administered to patients undergoing surgery to critically ill for sedation.Clinically, the development of hyperglycemia in critically ill patients and patients patients for sedation
Hepatic tissues expressed a relatively constant level of glucagon-like peptide-1 receptor fibroblast growth factor receptor-1 (FGFR1), implying an action of fibroblast growth factor-21 (FGF-21)
Propofol is widely used for general anesthesia during surgery
Summary
Anesthetics administered to patients undergoing surgery and to and critically ill patientsAnestheticsare areroutinely routinely administered to patients undergoing surgery to critically ill for sedation.Clinically, the development of hyperglycemia in critically ill patients and patients patients for sedation. Anesthetics administered to patients undergoing surgery and to and critically ill patients. Anestheticsare areroutinely routinely administered to patients undergoing surgery to critically ill for sedation. The development of hyperglycemia in critically ill patients and undergoing surgery issurgery associated with an increase morbidity, andmorbidity, certain complications. Forintensive patients in theunit intensive unit (ICU),ofthe prevalence of(>180 hyperglycemia In particular halothane, isoflurane, and sevoflurane, cause impaired glucose insulin resistance. In particular halothane, isoflurane, and sevoflurane, tolerance, insulin resistance, and hyperglycemia, suggesting active roles suggesting in surgery- active and critically cause impaired glucose tolerance, insulin resistance, and hyperglycemia, roles in ill-accompanied hyperglycemia [3,4,5]
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