Abstract
A previous study of the cerebral effects of propofol reported that the propofol caused an initial decrease of cerebrospinal fluid (CSF) pressure and cerebral blood flow, followed by a return of CSF pressure to control values despite continued administration of propofol and continued decrease of cerebral blood flow. One explanation for the return of CSF pressure to control values is that propofol may cause an increase of the rate of CSF formation or of resistance to reabsorption of CSF. The present study was designed to examine the effects of low, moderate, and high doses of propofol, given with either fentanyl or halothane, on the rate of CSF formation and resistance to reabsorption of CSF. The rate of CSF formation and resistance to reabsorption of CSF were determined in 12 rabbits using the technique of ventriculocisternal perfusion. In the propofol-fentanyl group (n = 6), the fentanyl dose was 100 micrograms/kg followed by 20 micrograms x kg-1 x h-1 i.v., and in the propofol-halothane group (n = 6), the concentration of halothane was 0.8 to 1.0%. For both groups, the three doses of propofol were 6 mg/kg followed by 12 mg x kg-1 x h-1, 24 mg x kg-1 x h-1, and 48 mg x kg-1 x h-1 i.v., respectively. In both groups, propofol caused no significant change of the rate of CSF formation or resistance to reabsorption of CSF.(ABSTRACT TRUNCATED AT 250 WORDS)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.