Propofol combined with fentanil or ketamine for anesthesia in drug abusers

Abstract

Objective To investigate the effect of propofol combined with fentanil or ketamine for anesthesia in drug abusers. Methods 516 drug abusers were randomly assgined to receive continuous preoperative injection of propofol of 2.5-3 mg/kg and then either intravenous fentanil of 2-3 μg/kg (258patients, group Ⅰ ) or ketamine of lng/kg (258 patients, group Ⅱ). Additional doses of fentanil or ketamine were added when necessary. Blood pressure, ECG and SpO2 were continuously monitored. Results As compared with the baseline values, MAP and HR significantly decreased in group Ⅰ (P＜ 0.05), while increased in group Ⅱ (P＜0.05); there was no significant difference in SpO2. No abstinent symptoms occurred in all the patients. Conclusions Propofol combined with fentanil or ketamine can not only prevent and treat abstinent symptoms but also enhance anesthestic effect. lntraoperative monitoring should be enhanced and the stability of respiration and circulation system should be maintained. Key words: Drug abuse; Propofol; Fentanil; Ketamine