Abstract
A rapid, accurate and sensitive UV derivative method was described for measuring the Propofol concentration in some biological fluids. Furthermore two alternative procedures, a gaschromatographic and a colorimetric, were also defined, and the results of the three methods, when applied on blood samples spiked with known amounts of analyte, were compared. The samples were preliminary purified by a solid phase extraction on octadecyl C18 cartridge. The UV derivative method was applied to a pharmacokinetic study on pregnant women undergoing cesarean sections. After an induction dose administration of 2.5 mg kg −1, the maternal and the umbilical vein blood were found to have comparable concentrations of propofol, with a mean half life of about 3.5 min; on the contrary no detectable levels of the drug were found in amniotic fluid. The drug recoveries were >98% and the response was linear over the range 0.05–40 μg ml −1.
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