Abstract
The present study investigated the effects 12 times normal atmospheric pressure (pressure) on propofol and ethanol potentiation of α1 and α2 glycine receptors (GlyRs) expressed in Xenopus oocytes using two-electrode voltage clamp. Pressure significantly antagonized potentiation by high, but not low, ethanol concentrations in α1 GlyR. Pressure did not antagonize ethanol at any concentration in α2 GlyR. These findings paralleled prior studies with ethanol and butanol. In contrast, pressure antagonized propofol at all concentrations in both α1 and α2GlyRs. These findings suggest that propofol acts on different sites or by different mechanisms than ethanol and butanol in GlyRs.
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