Abstract
The effects of propionil-L-carnitine on exercise tolerance of 12 patients with stable exertional angina were assessed in a double-blind, placebo-controlled, cross-over protocol using serial exercise tests. Compared to placebo, propionil-L-carnitine significantly increased total work from 514 ± 199 to 600 ± 209 W ( P < 0.05) (17%) and prolonged exercise time and time to ischemic threshold from 515 ± 115 to 565 ± 109 sec ( P < 0.05) (10%) and from 375 ± 102 to 427 ± 93 sec ( P < 0.01) (14%), respectively. ST segment depression at the highest common work level was significantly reduced from 0.19 ± 0.08 to 0.15 ± 0.08 mV ( P < 0.05) (21%). No significant changes in heart rate, systolic blood pressure, and rate-pressure product at rest, at the highest common work level, on appearance of the ischemic threshold, or at peak exercise were observed after propionil-L-carnitine treatment. No side effects were observed under propionil-L-carnitine treatment. This study shows that propionil-L-carnitine can significantly improve exercise tolerance in patients with stable angina. Our data seem to confirm that propionil-L-carnitine most likely exerts its protective action via the metabolic pathway.
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