Abstract
Received for publication February 21, 1951. * This work was submitted in partial fulfillment for the Master of Science Degree at the Department of Bacteriology, University of Illinois College of Medicine, Chicago, 111. Ercoli,9 in 1945, reported that a dose of penicillin delayed the death of guinea pigs infected with cultures of C. diphtheriae; also, that penicillin exerted a marked activity against systemic, mainly bacillary, infections in mice. In the same year, Young and Mood10 observed that penicillin was very active in extremely small amounts in preventing diphtheritic infections and fatal toxemia in guinea pigs. Recently, prolonged therapeutic blood levels have been obtained following a single injection of penicillinprocaine.11'12 Inhibitory levels have been maintained for as long as 4 or 5 days. The possibility of using penicillinprocaine as a prophylactic agent against diphtheritic infections suggests itself. Our results in experimental animals indicate that protection may be obtained with its use.
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