Abstract
An aromatic analog of retinoic acid, ethyl all-trans- 9-( 4-methoxy- 2,3,6-trimethylphenyl)- 3,7-dimethyl- 2,4,6,8-nonatetraenoate (= Ro 10-9359), has been found to possess a prophylactic effect on the development of skin papillomas and carcinomas of mice induced by 7,12-dimethylbenzanthracene and croton oil. The daily oral application of 30 mg/kg Ro 10-9359—given during the promotion phase of carcinogenesis-delayed the appearance and retarded the growth of papillomas and reduced the incidence of carcinomas. Considering the low toxicity of Ro 10-9359, its preventive action on epithelial tumors is very remarkable.
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