Prophylaxis against acute pulmonary edema and death in dogs with aortic insufficiency following renal artery constriction afforded by prior construction of an atrial septal defect.

Abstract

Prophylaxis against acute pulmonary edema and death in dogs with aortic insufficiency following renal artery constriction by prior constriction of an atrial septal defect. Dogs with the combined cardiac lesions of atrial septal defect and aortic insufficiency were studied. The atrial septal defects were large and were produced under direct vision. The present studies indicate that when such dogs are subjected to renal artery constriction (RAC) they neither die acutely (within 2 days) nor develop acute massive pulmonary edema. These dogs develop varying patterns of ‘congestive failure’ after RAC. The severity and course of this ‘congestive failure’ seemed to depend upon either the size of the aortic valvular ‘leak’ or the degree of RAC produced in a particular dog.