Abstract
1506Background: Despite the benefits of risk reducing salpingo-oophorectomy (RRSO) for BRCA 1/2 mutation carriers, the adverse effects of surgical menopause on young women are problematic. Mounting evidence suggests the fallopian tube is the site of origin of BRCA-associated ovarian malignancies. However, no data exist to demonstrate whether salpingectomy lowers the risk of developing ovarian cancer (OC) in women with BRCA mutations. We conducted a feasibility study of PSDO to determine patient acceptance, and to evaluate pathology results and sexual function. Methods: Eligibility criteria included pre-menopausal women with BRCA mutations ages 30 to 47 years recruited from 2 academic centers with high risk clinics and gynecologic oncology programs. Patients (pts) chose one of 3 arms: screening, RRSO, or PSDO. Completion oophorectomy is recommended at age 39 for BRCA1 and age 45 for BRCA2 pts. All pts were seen twice yearly with CA125 and transvaginal ultrasound. Quality of life, sexuality, and menopausal ...
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