Prophylactic intrapartum amnioinfusion: A randomized clinical trial

Abstract

Amnioinfusion was performed in a prospective, randomized trial of 60 women in the latent phase of labor with oligohydramnios, as defined by an amniotic fluid index ≤5.0 cm. All fetuses were at least 37 weeks' gestational age, had normal baseline fetal heart rate variability, and no clinically significant fetal heart rate decelerations at the outset. Subjects in the amnioinfusion group ( n = 30) were titrated to and maintained at an amniotic fluid index level ≥8.0 cm throughout labor. In the group receiving amnioinfusion, significantly lower rates of meconium passage ( p = 0.04), severe variable decelerations ( p = 0.04), end-stage bradycardia ( p = 0.05), and operative delivery for fetal distress ( p = 0.002) occurred. Significantly higher umbilical arterial blood pH values were also noted in the infusion group ( p = 0.02). We conclude that prophylactic intrapartum amnioinfusion is an important technique for the reduction of intrapartum morbidity.