Abstract
Recently a meta-analysis showed an improved survival probability of prophylactic cranial irradiation (PCI) in limited disease small-cell lung cancer (LD SCLC) in complete remission after chemotherapy.We evaluated treatment results of PCI+and PCI−in these patients. Whether PCI (n=65) or no PCI (n=37) was administered did not depend either on patients or on tumour characteristics.After 2 years the incidence of brain metastases was 11% in PCI+patients and 51% in PCI−patients. Both disease-free survival and overall survival were significantly longer after PCI.PCI reduces the incidence of brain metastases, prolongs brain metastases-free period, and overall survival in LD SCLC patients in complete remission after chemotherapy.
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