Abstract
Introduction:Different prophylactic methods are introduced to prevent surgical site Infection. This study was conducted to evaluatesituation of prophylactic antibiotics (PA) usage in an Iranian university hospital.Aims:A cross sectional study.Methods:This study obtained data from 1010 patients’ medical files in 2015. These patients were admitted to a university otolaryngology (ENT) and ophthalmology hospital in north of Iran. Data from ordered prophylactic antibiotics considering induction time, type of antibiotic, duration of use, dosage amount and intervals was obtained to compare with international and national guidelines. Data analysis was performed by using Chi-square test at significance level of 95%.Results:402 (39.8%) patients were male and 608 (60.2%) ones were female. Mean age and standard deviation was 41.8±22.3 years old, and most participants were in 20-39 years of age. Ophthalmic and ENT related procedure was respectively conducted for 41.7% and 58.3% of patients. Septorhinoplasty and phacoemulsification were the commonest procedures. Totally 999 (98.9%) people received prophylactic antibiotics. Intravenous Cefazolin (for ENT procedures) and topical eye drop of Chloramphenicol 0.5% were prescribed mostly. We found poor accommodation between antibiotic use and guidelines for prophylaxis, mostly in case of duration of apply.Conclusion:Ordered prophylactic antibiotics is not as need as prescribed. Also, accommodation between prescription of antibiotics and available scientific guidelines was improper in this study.
Highlights
Different prophylactic methods are introduced to prevent surgical site Infection
In terms of prophylactic antibiotics (PA) prescription, we tried to answer “What kind of antibiotic was selected for patient?”, “When the first dose was administrated relative to the procedure?”, “How was the route of administration, oral or intravenous?”, “What was the dose of consumption?”, “How was the interval between dosage?” and “How long antibiotic was continued post-operatively?” for every participants based on drug data registered in patients’ medical file
Of all 1010 patients, 402 (39.8%) were males and 608 (60.2%) were females, and 589 (58.3% were in ENT ward and 421(41.7%) in ophthalmology wards
Summary
Different prophylactic methods are introduced to prevent surgical site Infection. This study was conducted to evaluatesituation of prophylactic antibiotics (PA) usage in an Iranian university hospital. Based on American Society of Health Protection (ASHP) instructions, protocols of using antibiotics have been recommended for SSI prophylaxis in different procedures, but there is no comprehensive consensus on how and which antibiotics should be whether use or not that prevent SSI incidence in borderline clean-contaminated procedures [8]. This issue may be more controversial when some studies reported that the lower adequacy of using prophylactic antibiotics whether in type selection or first dose
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