Abstract
Summary and Conclusions1. Progressive acute disseminated encephalomyelitis was produced in 90% of a group of guinea pigs by the subcutaneous injection of water in oil emulsions of homologous brain tissue plus adjuvants.2. While prophylaxis and treatment with moderate dosages of either para-aminobenzoic acid or sodium salicylate alone provided no protection of guinea pigs against experimental allergic encephalomyelitis, the use of larger dosages of salicylate as well as combined salicylate and para-aminobenzoic acid therapy were effective in preventing this disease.3. Effective prophylaxis was demonstrated only when the medication was started before or shortly after the sensitizing injection of brain tissue was given.4. No therapeutic effect of sodium salicylate alone or combination of para-aminobenzoic acid with sodium salicylate could be shown.
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