Abstract
The kinetics of production of murine leukemia virus from two different C3H mouse embryo cell lines have been studied. Parameters of virus expression in vitro included assays for particles containing DNA polymerase activity and for XC plaque-forming ability. Particles containing DNA polymerase were produced at similar rates from chemically transformed, IUdR-treated C3H/10T1/2 cells and from spontaneously transformed, IUdR-treated C3H/10T1/2 cells. However, only the former cell line produced virus capable of forming XC plaques. Host range analysis for productive infection revealed that the XC − virus was 1000- to 10,000-fold less infectious than the XC + virus.
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