Properties of turpentine relative to the effects on fowl plasma in vitro. I. The simulation of "leukemic" changes in normal plasma.

Abstract

The addition of some turpentines to avian plasma in vitro caused α-lipoprotein changes similar to those seen in electropherograms of plasma from birds affected with erythroblastosis. The effective turpentines were old oxidized samples containing large amounts of acids and peroxides. Acids, pure peroxides, and cationic soaps had similar effects on plasma but much more material was required. Neither the acids nor the peroxides could be shown to be the cause of the plasma changes but their presence was indicative of activity of turpentine on plasma lipoproteins. The α-lipoprotein changes which appear to result from many different treatments are discussed in terms of possible common mechanisms.