Abstract

Four strains of tick-borne encephalitis virus transfected by DNA from chronically infected cells were studied. The viruses induced cytopathic effect in a line of swine embryo kidney cells and inapparent infection in suckling mice. Treatment of the cells with DEAE-dextran increased infectious titres and cytopathic action of the viruses. One substrain revealed an extreme degree of attenuation and showed cytopathic activity only in the presence of DEAE-dextran.

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