Abstract
Constructing surface coatings is an effective way to improve the corrosion resistance and biocompatibility of magnesium alloy bioabsorbable implants. In this present work, a titanium oxide coating with a thickness of about 400 nm was successfully prepared on a MgZn alloy surface via a facile magnetron sputtering route. The surface features were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and the contact angle method. The corrosion behavior and biocompatibility were evaluated. The results indicated that the amorphous TiO2 coating with a flat and dense morphology was obtained by magnetron-sputtering a titanium oxide target. The corrosion current density decreased from 1050 (bare MgZn alloy) to 49 μA/cm2 (sample with TiO2 coating), suggesting a significant increase in corrosion resistance. In addition, the TiO2 coating showed good biocompatibilities, including significant reduced hemolysis and platelet adhesion, and increased endothelial cell viability and adhesion.
Highlights
Magnesium alloy (Mg alloy) is an excellent biological material for bioabsorbable implant applications, due to its low corrosion resistance, good biocompatibility, and mechanical properties [1,2].In recent years, cardiovascular stents made from absorbable Mg alloys have been developed to overcome the drawbacks of permanent metallic stents, including late-term restenosis, delayed re-endothelialization, and persistent inflammation [3,4]
The new electrons fly to the substrate, and Ar+ ions accelerate to fly to the cathode TiO2 target and bombard the target surface with high energy to make the target sputtering
The results prove that the 400 nm-thick TiO2 coating can provide effective corrosion protection for the Mg alloy
Summary
Magnesium alloy (Mg alloy) is an excellent biological material for bioabsorbable implant applications, due to its low corrosion resistance, good biocompatibility, and mechanical properties [1,2].In recent years, cardiovascular stents made from absorbable Mg alloys have been developed to overcome the drawbacks of permanent metallic stents, including late-term restenosis, delayed re-endothelialization, and persistent inflammation [3,4]. In order to solve this problem, surface modifications have been widely carried out to prepare suitable coatings onto Mg alloys as corrosion protective layers, and to improve their biocompatibility and mechanical stability [5,6,7,8,9]. For Mg alloy cardiovascular stents, some organic-based coatings, such as polylactic acid (PLA) [7], polydopamine (PDA) [10,11], poly (lactic-co-glycolic acid) (PLGA) [12], and polytrimethylene carbonate (PTMC) [13], have been commonly used as corrosion protection layers or drug delivery carriers to prevent the in-stent restenosis (ISR). Inorganic coatings can be prepared by various methods, providing a superior adhesion with substrates.
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