Abstract
Using the physical methods of unit gravity (1 g) sedimentation and column filtration (Sephadex) on the rat collagenase-dispersed adrenal gland (either capsule or decapsulated gland), purified preparations of all three cell types, zonae glomerulosa, fasciculata and reticularis, were obtained. Morphological studies have determined the modal diameters of the cells to be: zona glomerulosa, 10.5 μm; zona fasciculata, 18 μm; zona reticularis, Type I, 9 μm, and Type II, 13 μm. All types of adrenal cell produced at least one corticoid in common, corticosterone. Zona glomerulosa cells responded to small changes in potassium ion (K+) concentration (× 2.3 corticosterone output), angiotensin II (× 1.7 corticosterone output), ACTH (x 3 corticosterone output) and in vitro, serotonin (× 2.1 corticosterone output). Aldosterone was produced exclusively by the zona glomerulosa cells.
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