Abstract
Half of the population sustains at least one fracture during their lifetime [1], and the majority of these fractures heal successfully. Successful fracture healing requires the following five elements; (i) osteogenic cells (e.g., osteoblasts), (ii) osteoinductive stimuli (e.g., bone morphogenetic proteins); (iii) an osteoconductive matrix; (iv) adequate blood and nutrient supply, and (v) sufficient mechanical support [2]. One or more elements can be compromised due to the existence of a bone defect.
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