Abstract
Various biological and chemical properties of colostrokinin were studied. Vasodilatation in dogs, stimulation of smooth muscles of rats and increasing capillary permeability in guinea pigs were observed as the pharmacological actions. Among these, the change in capillary permeability is the strongest when compared to the activity of bradykinin. Colostrokinin activity is destroyed by chymotrypsin, but only slightly by trypsin. It is more stable in acid than in alkaline solution. This substance is dialyzable, and is soluble in water, in 67% ethanol and in 75% acetone, but not in absolute acetone. The isoelectric point is close to pH 7.4. Phenylalanine and serine were detected as the N-terminal and the C-terminal amino acids respectively. The molecular weight, on the basis of amino acid analysis, was calculated to be about 2000. Colostrokinin absorbs light close to λ = 260 m μ.
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