Properties of biomineralized (CaCO3) PVP-CMC hydrogel with reference to its cytotoxicity

Abstract

ABSTRACTThe authors focus on properties of biomineralized (CaCO3) PVP-CMC hydrogel (designated as I–X) including cytotoxicity assay using primary mouse embryonic fibroblasts. The biomineralized samples (VII–X) showed >80% cell viability, was selected for further characterizations. FTIR and XRD indicate deposition of CaCO3 within the PVP-CMC hydrogel matrix, SEM shows changes in morphology and pore diameter (VII and VIII: 1–12 µm; IX: 10–70 µm; X: 70–170 µm), TGA determines the decomposition scenario of CaCO3, and tensile strength of samples (VII–X) ranged between 0.04 and 1.0 GPa, which practically corresponds to the modulus of cancellous bone.