Abstract
RNA synthesis has been studied in a strain of Escherichia coli which has lost amino acid control over this process. It was found that this strain is capable of a normal, physiological control of RNA synthesis under most conditions of balanced or unbalanced growth. It exhibits a normal correlation of RNA: protein ratio with growth rate in most media, and can halt RNA accumulation during adjustment to a poorer medim. In several conditions of cultivation, however, regulation of RNA synthesis by these cells breaks down, and they accumulate unusual amounts of RNA. Evidence is presented that all these conditions impose an amino acid restriction on the cells.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects
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