Properties and temporal dynamics of choice- and action-predictive signals during item recognition decisions

Abstract

Decision-making is in the service of action regardless of whether the decision concerns perceptual information, goods or memories. Compared to recent advances in the neurobiology of perceptual or value-based decisions, however, the neural bases supporting the sampling of evidence in long-term memory, and the transformation of memory-based decisions into appropriate actions, are still poorly understood. In the present fMRI study, we used multivariate pattern analysis to investigate the temporal dynamics of choice- and action-predictive signals during an item recognition task that manipulated the association between memory choices (old/new) and motor responses (eye/hand) across subjects. Choice-predictive activity was mainly observed in striatal, lateral prefrontal and lateral parietal regions, was sensitive to the amount of decision evidence and showed a rapid increase after stimulus onset, followed by a fast decay. Action-predictive signals were found in primary sensory motor, premotor and occipito–parietal regions, were generally observed at the end of the decision phase and were not modulated by decision evidence. These findings suggest that a memory decision variable, potentially represented in a fronto–striato–parietal network, is not directly transformed into an action plan as often observed in perceptual decisions. Regions exhibiting choice predictive activity, and especially the striatum, however, also showed a second peak of decision-related activity that, unlike pure choice- or action-predictive signals, depended on the particular choice–response association. This second peak of activity in the striatum might represent the neural signature of the transformation of a memory decision into an appropriate motor response based on the specific choice–response association.