Abstract
Regulation of effector T cells by regulatory T cells (Treg) is an essential mechanism for induction and maintenance of peripheral immune tolerance. Treg cells represent functionally and phenotypically distinct specialized subpopulations of T lymphocytes and are derived from the thymus or induced in the periphery. In humans, CD4+CD25+FoxP3-expressing T cells represent by far the best-characterized population of thymus-derived Treg (tTreg) cells. Recently, our group has described another subpopulation of CD4+ tTreg cells characterized by the expression of the non-classical major histocompatibility complex class I molecule human leukocyte antigen G (HLA-G), which is involved in immune regulation and parenchymal homeostasis during infectious and autoimmune inflammation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
