Abstract

Human lymphoid cells seem to be interesting models for the study of the expression of nucleotide-degrading ectoenzymes, since extreme differences in enzyme activities are observed between subpopulations of normal peripheral blood lymphocytes (Silber et al. 1975; Thompson et al. 1983), different human T- or B-lymphoblastoid cell lines (Gutensohn et al. 1980), or malignant cells from patients with various forms of leukemias and lymphomas (Gutensohn and Thiel 1981; Gutensohn et al. 1983a). However, most of these investigations have sofar only included ecto-5′-nucleotidase. An interesting correlation of the expression of this enzyme with the presence of the so-called common ALL antigen (a 100 kD membrane glycoprotein) was observed in certain froms of acute leukemias (Gutensohn and Thiel 1981; Gutensohn et al. 1983a). However, this is obviously not reflected in a close association of these two markers on the plasma membrane level (Gutensohn et al. 1983b). In search for other enzymes which might be in closer contact with 5′-nucleotidase ATPase, ADPase and a nucleosidediphosphate kinase were studied and characterized on the surface of human lymphoid cells.

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