Abstract
Various compositions of Na 2O–CaO–P 2O 5 glasses are prepared to estimate glass formation, dissolution properties and cytotoxicity. In the wide composition range of 40 mol% of P 2O 5 or more, clear glass samples were obtained. The estimated glass forming region was consistent with other ternary phosphate glass systems. The glass transition temperatures and crystallization temperatures decreased with increasing P 2O 5 content and increased with CaO content. Dissolution properties in distilled water and simulated body fluid (SBF) were measured. In distilled water, CaO free glasses showed extremely fast dissolution. The dissolution rate decreased with increasing CaO content and decreasing P 2O 5 content. This composition effect results from cross-link formation between the non-bridging oxygens of two different chains by Ca 2+ ions which improves the phosphate network strength. In SBF, the dissolution rate followed a similar trend, but glass dissolution was suppressed. This suppression occurred due to the existence of soluble species of glass such as Na +, Ca 2+ and HPO 2- 4. The cytotoxicity decreased with increasing CaO content and with decreasing PO 2.5 content. This was the result of a change in pH and ion concentration in the medium.
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