Abstract
There is controversy regarding the prognosis of patients with oxyphilic thyroid cancer (OXTC). The present study compared the prognoses of OXTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Patient mortality was evaluated using Cox proportional hazards regression analyses and Kaplan-Meier analyses with log-rank tests. The multivariate Cox regression analysis revealed that the cancer-specific survival rate for OXTC was similar to that for PTC, but higher than that for FTC. However, after propensity score matching for relevant factors, the cancer-specific survival rate for OXTC was higher than that for PTC and FTC. This unexpected result provides new implications for the treatment of patients with OXTC.
Highlights
The incidence of thyroid cancer has risen rapidly during recent decades [1,2,3]
The present study compared the prognoses of oxyphilic thyroid cancer (OXTC), papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases
The multivariate Cox regression analysis revealed that the cancerspecific survival rate for OXTC was similar to that for PTC, but higher than that for FTC
Summary
Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) (i.e., differentiated thyroid cancer) account for >90% of all thyroid malignancies and are the most common types of thyroid carcinoma [1, 4, 5]. There are other rare histological variants of thyroid cancer, such as tall cell, solid, or oxyphilic thyroid cancer (OXTC) [6,7,8]. OXTC is known as Hurthle cell carcinoma, and only accounts for 2–5% of all thyroid cancers [9,10,11]. The present study compared the prognoses (cancerspecific and all-cause mortality) of OXTC, PTC, and FTC, using data from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2013) and propensity score matching (PSM)
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