Abstract
Endothelium-dependent relaxation of the vascular smooth muscles (SM) is responsible for the development of basic cardiovascular reactions, and its violation is the basis of aging-associated cardiovascular diseases. We studied effects of inhibiting cystathionine-γ-lyase (CSE), the enzyme for de novo synthesis of hydrogen sulfide, on the endothelium-dependent relaxation of thoracic aorta SM from old rats. It has been shown that an inhibition of CSE by propargylglycine (PAG) results in restoration of decreased ACh-induced relaxation of aortic SM in old rats. That effect of PAG was removed by blocking nitric oxide (NO) synthesis in the endothelial cells. Age-related changes in the levels of H2S2 NO2−and enzyme activity of the constitutive synthesis of NO (cNOS) in the heart were determined. It has been demonstrated that introduced PAG elevates decreased levels of H2S2 NO2−and stimulates suppressed activity of cNOS in old rats. These results suggest that PAG activates alternative ways of H2S synthesis and stimulates the constitutive synthesis of NO to restore endothelial function in old rats.
Published Version
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