Abstract
Prooxidant and antioxidant processes in the liver homogenate of healthy and tumor-bearing mice under the action of thiazole derivatives
Highlights
A lmost all the chemotherapy agents have negative side effects when antitumor drugs damage healthy cells, in particular hepatocytes
In the liver of tumor-bearing mice, control levelwere higher by 13.0% and 14.7%, respectively (P = 0.05 by Wilcoxon test). Both substancesdid not significantly change the levels of hydroperoxides in the liver of healthy and tumorbearing mice. These results indicate that the tested substances do not affect the level of primary products of lipid peroxidation
Because hydroperoxides rapidly enter into other redox reactions and become a source of secondary products of lipid oxidation (LPO), the step of the study was to test the content of second LPO products in the livers of mice in both groups under the action of the tested substances
Summary
A lmost all the chemotherapy agents have negative side effects when antitumor drugs damage healthy cells, in particular hepatocytes. The productsof tumor development during its growth in the body can affect the balance of prooxidant and antioxidant processes in other organs, including the liver [5]. The changes in free radicals and antioxidant processes in liver cells may suggest the possible mechanisms of negative side effects that often occur after using antitumor drugs. The purpose of this work was to investigate the effect of thiazole derivatives on the level of primary and secondary products of peroxide lipid oxidation (LPO), superoxide radicals and the activity of enzymes of the antioxidant defense in the mouse liver with or without NK/Ly lymphoma and to compare the studied parameters in the liver of healthy mice and tumor-bearing mice
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