Abstract
ObjectiveOur research group was aim to explore the molecular mechanism of Talin‐1 protein affecting gastric cancer progression through PTK2‐PXN‐VCL‐E‐Cadherin‐CAPN2‐MAPK1 signal axis.Methods12 cases of patients with gastric cancer in this hospital from 2018 to 2019 were collected. Immunohistochemistry assay and Western blotting were used to detect the expression of Talin‐1, PXN, E‐Cadherin, CAPN2, MAPK1 protein in gastric cancer tissue. Cell migration and invasion were measured by Transwell.ResultsThe results showed that the expression levels of protein Talin‐1, PXN and MAPK1 in gastric cancer tissues were significantly higher than that in normal tissue. The number of cell adhesion in the model group was significantly lower than that in the normal group. However, the cell adhesion number in ov‐TLN1 was the highest. Transwell results showed that TLN1 could accelerate the migration and invasion abilities of gastric cancer MKN‐45 cells. Moreover, Western blotting showed that protein Talin‐1, PXN, E‐Cadherin, CAPN2, MAPK1 in model group all increased compared with normal group.ConclusionIt indicated that talin‐1 protein influenced the development of gastric cancer through PTK2‐PXN‐VCL‐E‐Cadherin‐CAPN2‐MAPK1 signal axis.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
