Abstract
Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague–Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.
Highlights
It has been found that a number of marine microorganisms synthesize exopolysaccharides (EPSs) [1]
16th day, there waswas no visible wound on the skin treated with mg/mL. These results clearly show that can promote rat skin treated with 5 mg/mL EPS. These results clearly show that SM1127 EPS can promote rat skin wound wound healing.healing
The skin morphology and architecture of the control group were incomplete. These results indicate that SM1127 EPS can accelerate tissue regeneration when applied to skin wounds
Summary
It has been found that a number of marine microorganisms synthesize exopolysaccharides (EPSs) [1]. The EPS from the marine bacterium Pseudomonas stuzeri 273 combats bacterial biofilm-associated infection [13] These studies show the medical potential of EPSs from marine microorganisms. It is necessary to further study the pharmaceutical applications of marine EPSs. Skin, the largest organ in human and animal bodies, mainly protects the body against toxins, microorganisms, and some other potential insults and continuously maintains life. A number of EPSs from marine microorganisms have been studied, no marine EPS has been reported to be applied in wound healing. SM1127 EPS has no oral toxicity and is nonirritating to skin according to safety evaluation [24] Due to these good properties of SM1127 EPS, it is necessary to further probe its pharmaceutical potential. Full-thickness cutaneous wound experiments and frostbite injury experiments were performed to investigate the effects of SM1127 EPS on rat skin wound healing and frostbite injury prevention
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
