Abstract
SSP1, a polysaccharide isolated from Sophora subprosrate, increased the productions of nitric oxide (NO) and interleukin-2 (IL-2) in murine splenic T lymphocytes. SSP1-treated T lymphocytes showed an enhanced activity of protein kinase C (PKC) from the cellular membrane fraction as well as an increase in concentration of cytoplasmic free Ca 2+. The results showed that SSP1 activated T cells to release NO and secrete IL-2 by modulating activity of PKC and level of intracellular free calcium. Nifedipine, a Ca 2+ blocker, inhibited the activation of T cells by SSP1, indicating a role of Ca 2+ in the activation of T cells. SSP1-treated T cells showed an enhanced translocation of PKC, indicating that SSP1 activated T cells via the activation of PKC.
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