Abstract
The purpose of the present study was to address the question of whether environmental stress affects the age of onset and incidence of overt insulin-dependent diabetes mellitus in an animal model of human Type 1 (insulin-dependent) diabetes. Thirty-five diabetes prone BB rats of both sexes were divided into two groups: experimental animals were exposed to multiple, concurrent, and unpredictable environmental stressors, while littermate controls were exposed to a standard lab environment. Groups were housed in two separate, sound attenuated, independently ventilated, and restricted rooms. By age 150 days, experimental group animals had developed overt diabetes at a significantly earlier age.
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