Promotion Effects of Yeast Hydrolysates and a Mixture of Safflower Seed and Gasiogapi Extract on Longitudinal Bone, Proximal Epiphysis, and Growth Hormone in Rats

Abstract

This study examined the growth effects of yeast hydrolysate (YH) and a traditional Korean herbal mixture (HM, a mixture of safflower seed and gasiogapi extract). Three-week old male SD rats were divided into the following five groups: negative control (saline), positive control (foremilk 0.5 g/㎏/day), YH (YH 0.5 g/㎏/day), HM (HM 0.2 g/㎏/day), and YH＋HM (YH 0.5 g/㎏/day and HM 0.2 g/㎏/day). Tibia bone length was 9.22 ㎜ in the normal control rats, while both the YH and YH＋HM groups had significantly longer tibia bones than the control rats (9.75 ㎜ and 10.46 ㎜, respectively). The proximal epiphyses of YH, HM, and YH＋HM measured 0.75, 0.70, and 0.75 ㎜, respectively, while the length in the control group was 0.50 ㎜. Plasma insulin growth factor-1 (IGF-1) level was slightly higher in the YH group (1.36 ㎎/㎖) than in the control rats (1.29 ㎎/㎖), but the difference was not significant. Plasma IGF-1 level was significantly increased in the HM (1.49 ㎎/㎖) and YH＋HM (1.53 ㎎/㎖) groups compared to the control group (1.29 ㎎/㎖). Growth hormone (GH) levels in YH (17.45 ng/㎖), HM (15.49 ng/㎖), and YH＋HM (16.07 ng/㎖) were significantly different compared to the control group (3.63 ng/㎖).